Table 3:

Risk Factors associated with venous thromboembolism (VTE) recurrence and bleeding after incident VTE among California sickle cell disease (SCD) patients

	VTE Recurrence			Bleeding
Variables	HR	95% CI	P-Value	HR	95% CI	P-Value
Gender
Female	1.23	(0.93, 1.62)	0.1458	1.00	(0.69, 1.44)	0.9988
Male	Ref	-	-	Ref	-	-
Race/Ethnicity
African-American	Ref	-	-	0.84	(0.38, 1.83)	0.6549
Non-African American	0.96	(0.55, 1.68)	0.8797	Ref	-	-
SCD Severity
Less Severe	Ref	-	-	Ref	-	-
More Severe SCD	2.33	(1.63, 3.32)	<.0001	2.26	(1.41, 3.64)	0.0008
Incident VTE Year
1991-2002	Ref	-	-	Ref	-	-
2003-2014	0.88	(0.67, 1.15)	0.3353	1.15	(0.80, 1.66)	0.4425
Age at Incident VTE
<25	Ref	-	-	Ref	-	-
25-39	1.09	(0.81, 1.48)	0.5692	1.13	(0.72, 1.76)	0.6004
40-54	0.89	(0.60, 1.31)	0.5489	1.51	(0.90, 2.56)	0.1218
≥55	0.50	(0.23, 1.06)	0.0721	2.35	(1.22, 4.55)	0.0110
Incident VTE Location
PE	Ref	-	-	Ref	-	-
DVT	1.78	(1.29, 2.46)	0.0005	1.07	(0.70, 1.63)	0.7482
UE	1.07	(0.73, 1.55)	0.7399	1.24	(0.78, 1.97)	0.3691
Incident VTE Hospitalization Associated Status
Yes	0.83	(0.61, 1.13)	0.2285	1.14	(0.78, 1.68)	0.4950
No	Ref	-	-	Ref	-	-
Prior Bleeding
Yes	1.24	(0.88, 1.75)	0.2235	1.04	(0.65, 1.66)	0.8755
No	Ref	-	-	Ref	-	-
SCD Complication prior to outcome
*ONFH
Yes	1.01	(0.76, 1.34)	0.9591	0.96	(0.67, 1.38)	0.8302
No	Ref	-	-	Ref	-	-
*Ischemic Stroke
Yes	1.23	(0.73, 2.07)	0.4298	1.24	(0.65, 2.39)	0.5170
No	Ref	-	-	Ref	-	-
*Pneumonia/ACS
Yes	1.73	(1.19, 2.50)	0.0037	1.01	(0.63, 1.61)	0.9697
No	Ref	-	-	Ref	-	-

Multivariable Cox proportional hazard regression model adjusted for the competing risk of other outcome and death

^*SCD complications were included as time dependent covariates

PE- Pulmonary Embolism

DVT- Lower extremity deep vein thrombosis

UE- Upper extremity deep vein thrombosis

ONFH- osteonecrosis of the femoral head

ACS- Acute chest syndrome