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. 2019 Nov 25;14(11):e0225586. doi: 10.1371/journal.pone.0225586

Fig 6. Inhibition of oxaliplatin-induced mechanical allodynia by ERK inhibitor PD98059.

Fig 6

PD98059 (6 μg day-1) or vehicle (20% DMSO) was injected i.t. for 4 weeks using an osmotic pressure pump. One week after the pump placement, oxaliplatin (4 mg kg-1) or vehicle (5% glucose) was injected i.p. twice a week for 3 weeks. von Frey test was done before the pump placement, and before and 1 week after each oxaliplatin or vehicle treatment (days 1, 2, 8, 9, 15, and 16). We confirmed the incidence of mechanical allodynia on day 22 (day 28 from pump placement). The hindpaw data within each group were analyzed using one-way repeated measures ANOVA followed by Bonferroni post hoc analysis. Welch’s test was used to compare between groups. All data are calculated as mean ± SEM of 5 animals. * P < 0.05, compared with Time -7 days (baseline). † P < 0.05, compared with OX + Veh at the same time.