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. 2019 Nov 19;10(62):6651–6667. doi: 10.18632/oncotarget.27286

Figure 1. NV669 inhibited pancreatic and liver cancer cell proliferation.

Figure 1

(A) The chemical structures of squalamine (7, 24 dihydroxylated 24-sulfated cholestane steroïd conjugated to a spermidine at C-3 top left), trodusquemine (top right), NV669 (bottom left) and claramine (bottom right). (B) BxPC3 and Huh7 cells were treated 72h with squalamine or NV669 at indicated concentrations. The cell viability was then assessed by the crystal violet assay. Black column, 0 μM; dark-grey column, 10 μM; grey column, 50 μM and white column, 100 μM. Values are means +/- SD of at least three independent experiments. (C) Effects of NV669 treatment on proliferation of BxPC3, MiaPaCa-2, HepG2 and Huh7. Cells were incubated with various doses of NV669 for 24h (full line) and 72h (dotted line) then analysed for cell proliferation using colorimetric dosage. Values are means +/- SD of at least six independent experiments.