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. 2019 Nov 11;129(12):5474–5488. doi: 10.1172/JCI121208

Figure 2. HFD accelerates disease progression and affects survival of SIV-infected NHPs.

Figure 2

Peripheral CD4+ T cell depletion in SIV-infected AGMs (A) and PTMs (E) are shown as index of baseline levels and compared at key time points of SIV infection within HFD group with the Friedman test corrected for multiple comparisons and between HFD and control groups with Kruskal-Wallis test. Plasma viral loads (B), PBMC-associated viral DNA (C), and intestinal cell-associated DNA (D) levels in SIV-infected AGMs, and in SIV-infected PTMs (F–H) were compared at acute and chronic infection between HFD and control groups with Kruskal-Wallis test. Data are presented as individual values with medians. Sample size (n) and P values are presented on graphs. BL, baseline (preinfection pre-HFD); Ac, acute infection; Chr, chronic infection; Fat, preinfection post-HFD; Nx, necropsy. Kaplan–Meier survival curves of SIV-infected PTMs (I) and AGMs (J) and PTMs are illustrated. Comparison between survival curves of HFD and control groups is performed with Mantel-Cox method. P values are presented on graphs.