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. Author manuscript; available in PMC: 2019 Nov 25.
Published in final edited form as: J Neural Eng. 2019 Oct 9;16(6):066003. doi: 10.1088/1741-2552/ab2610

Figure 15.

Figure 15

The proposed Chebyshev AFE architecture for artefact-free LFP recordings during unipolar DBS in vivo. LFP signals were recorded from the thalamus of an anaesthetised non-human primate in and without the presence of DBS with the experimental setup illustrated in figure 14. (a) Bipolar (differential) LFP recordings without DBS. (b) Bipolar (differential) LFP recordings during DBS. (c) Detailed view of the LFP recordings acquired without DBS. (d) Detailed view of the LFP recordings acquired during DBS. (e) Amplitude spectrum of the LFP signal recorded without DBS. (f) Amplitude spectrum of: (1) the LFP signal recorded during DBS (blue line), and (2) the stimulation pulses presented at the positive (red line) and negative (black line) inputs of the front-end instrumentation amplifier. It is clear that the proposed artefact suppression strategy (analog notch filtering at 140 Hz and digital low-pass filtering at 250 Hz) allows for artefact-free LFP recordings during DBS (observe the 142 Hz stimulation fundamental frequency, which has been strongly attenuated by the high-order notch filtering action).