Table 3.
Crude And Adjusted ORs And 95% CIs Of First AP Prescription Among Dementia Patients In The Lazio Region
| N | OR | 95% CI | ORadj | 95% CI | p-value | |||
|---|---|---|---|---|---|---|---|---|
| Gender | ||||||||
| Male | 600 | 0.98 | 0.90 | 1.07 | 1.12 | 1.01 | 1.24 | 0.039 |
| Age (years) | ||||||||
| 85+ | 555 | 1.00 | 1.00 | |||||
| 65–74 | 250 | 1.02 | 0.87 | 1.19 | 0.87 | 0.74 | 1.02 | 0.094 |
| 75–84 | 922 | 1.08 | 0.97 | 1.20 | 0.95 | 0.85 | 1.06 | 0.355 |
| Residence | ||||||||
| Municipality of Rome | 988 | 1.00 | 1.00 | |||||
| Other municipalities in the province of Rome | 327 | 0.86 | 0.75 | 0.98 | 0.88 | 0.77 | 1.00 | 0.054 |
| Other provinces of the Lazio region | 412 | 0.92 | 0.82 | 1.04 | 0.94 | 0.83 | 1.07 | 0.358 |
| Socio-economic position | ||||||||
| 1 (High) | 251 | 1.00 | 1.00 | |||||
| 2 | 421 | 0.99 | 0.98 | 1.00 | 0.89 | 0.76 | 1.05 | 0.166 |
| 3 | 448 | 0.99 | 0.98 | 1.00 | 0.92 | 0.78 | 1.08 | 0.315 |
| 4 (Low) | 273 | 0.99 | 0.98 | 1.00 | 0.89 | 0.74 | 1.06 | 0.191 |
| Not reported | 334 | 0.99 | 0.98 | 1.00 | 0.90 | 0.75 | 1.07 | 0.222 |
| Number of hospitalizations | ||||||||
| (2 years before date of enrolment) | ||||||||
| 0 | 989 | 1.00 | 1.00 | |||||
| 1 | 442 | 1.01 | 0.90 | 1.13 | 1.11 | 0.97 | 1.28 | 0.139 |
| 2 | 179 | 0.94 | 0.80 | 1.11 | 1.11 | 0.90 | 1.37 | 0.347 |
| 3+ | 117 | 0.79 | 0.64 | 0.96 | 0.99 | 0.75 | 1.32 | 0.969 |
| Cardiovascular risk factors | ||||||||
| (2 years before date of enrolment) | ||||||||
| Disorders of lipid metabolism | 53 | 1.20 | 0.90 | 1.59 | 1.23 | 0.91 | 1.66 | 0.185 |
| Hypertension | 274 | 0.92 | 0.80 | 1.05 | 1.04 | 0.88 | 1.23 | 0.622 |
| Ischemic heart diseasea | 81 | 0.76 | 0.60 | 0.96 | 0.89 | 0.69 | 1.14 | 0.357 |
| Heart failure | 64 | 0.80 | 0.62 | 1.03 | 1.05 | 0.79 | 1.40 | 0.723 |
| Cerebrovascular diseasesb | 260 | 0.91 | 0.80 | 1.05 | 1.06 | 0.90 | 1.25 | 0.506 |
| Coexisting comorbidities | ||||||||
| (2 years before date of enrolment) | ||||||||
| Malignant neoplasm | 71 | 0.94 | 0.74 | 1.21 | 0.99 | 0.76 | 1.29 | 0.955 |
| Diabetes | 103 | 0.75 | 0.61 | 0.92 | 0.84 | 0.67 | 1.05 | 0.129 |
| COPD | 81 | 0.73 | 0.58 | 0.92 | 0.90 | 0.70 | 1.16 | 0.432 |
| Fluid, electrolytes and base-acid balance disorders | 54 | 0.94 | 0.71 | 1.25 | 1.19 | 0.89 | 1.60 | 0.247 |
| Chronic kidney diseases | 66 | 0.76 | 0.59 | 0.98 | 0.94 | 0.71 | 1.24 | 0.667 |
| Pneumonia | 36 | 0.64 | 0.46 | 0.90 | 0.76 | 0.53 | 1.09 | 0.133 |
| Disease of the blood and blood-forming organs | 95 | 0.86 | 0.70 | 1.07 | 0.98 | 0.78 | 1.24 | 0.886 |
| Fracture of neck of femur | 70 | 1.21 | 0.94 | 1.55 | 1.28 | 0.98 | 1.68 | 0.070 |
| Depression | 7 | 1.33 | 0.61 | 2.90 | 1.23 | 0.56 | 2.71 | 0.611 |
| Drug use (at least 2 prescriptions) | ||||||||
| (2 years before date of enrolment) | ||||||||
| Antidepressant drugs | 887 | 1.80 | 1.63 | 1.99 | 1.67 | 1.51 | 1.85 | <0.0001 |
| Anti-dementia drugs | 1076 | 1.97 | 1.78 | 2.18 | 1.86 | 1.67 | 2.07 | <0.0001 |
| Polypharmacy (use of 6+ drugs), ATC 4° level | 1534 | 0.99 | 0.85 | 1.16 | 0.82 | 0.69 | 0.96 | 0.014 |
Notes: aIncluding previous cardiac revascularization; bincluding cerebrovascular revascularization.
Abbreviations: OR, odds ratio; CI, confidence intervals; COPD, chronic obstructive pulmonary disease; AP, antipsychotic.