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. 2019 Nov 21;11:9761–9769. doi: 10.2147/CMAR.S224097

Figure 2.

Figure 2

The effect of proton pump inhibitors on pegylated liposomal doxorubicin (PLD) delivery into monolayer-cultured cells at different pH values. (A) PLD fluorescence intensity in cells at different time periods at pH 7.4. (B) PLD fluorescence intensity in the cell nucleus at different time periods at pH 7.4. (C) PLD fluorescence intensity in cells at different time periods at pH 6.0. (D) DOX fluorescence intensity in the cell nucleus at different time periods at pH 6.0. (E) Representative images of cells after 4 hrs of incubation with DOX at pH 6.0. Magnification 600×. Scale bar = 50 µm. The asterisks (*) indicate p < 0.05.

Abbreviations: LANSO, lansoprazole; OME, omeprazole.