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The effect of proton pump inhibitors on pegylated liposomal doxorubicin (PLD) delivery into tumor spheroids at different pH values. (A) Fluorescence intensity of PLD in spheroids affected by lansoprazole and omeprazole at pH 7.4 and 6.0. (B) Representative images of spheroids after different times of incubation with PLD at pH 7.4 and 6.0. Magnification 100×. Scale bar = 200 µm. The asterisks (*) indicate p < 0.05.
Abbreviations: LANSO, lansoprazole; OME, omeprazole.
