Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 19;13:513. doi: 10.3389/fncel.2019.00513

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Cingolani, Vitale and Dityatev.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Metabotropic glutamate receptors 1/5 (mGluR1/5) in long-term depression (LTD) and homeostatic synaptic plasticity (HSP). Top, in LTD, mGluR1/5 are anchored at perisynaptic sites via Homer 1b/c and activated in a synapse-specific manner by synaptically released glutamate. Activation of mGluR1/5 leads to tyrosine dephosphorylation of the GluA2 subunit of AMPARs (1), with consequent increase in AMPAR endocytosis (2). Bottom, in HSP induced by chronic increase in network activity, induction of Homer1a decouples mGluR1/5 from the synaptic signaling machinery and induce a constitutive glutamate-independent activation of mGluR1/5. Homer1a-induced mGluR1/5 signaling requires upregulation of the striatal-enriched protein tyrosine phosphatase (STEP61; 1), with consequent dephosphorylation of the GluA2 subunit of AMPARs (2) and increase in AMPAR endocytosis (3) in a non-synapse-specific manner.