Fig. 1.

CT26 tumor development following DaRT + TLR3 agonist. a Experimental scheme. CT26-bearing mice were treated with either a 40 kBq DaRT seed or inert seed; 72 and 24 h prior to seed insertion, an intratumoral (i.t.) injection of 10 µg/30 µl poly I:C or PBS was given. b Tumor growth curve. DaRT + poly I:C reduced tumor growth compared to all other groups. p_{t test} < 0.05 for DaRT + poly I:C vs. control on days 3, 13 and 14, vs. DaRT alone on days 4–8, and vs. poly I:C alone on days 3, 8–10, 12, 13