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. 2019 Oct 22;68(12):1949–1958. doi: 10.1007/s00262-019-02418-5

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Rechallenge tumor development in CT26-bearing mice treated with DaRT vs. inert seed combined with immunomodulators. Mice were inoculated with 5 × 10⁵ CT26 tumor cells and then treated with DaRT or inert seeds combined with immunomodulators CpG, CP, and sildenafil. Cured mice or tumor-resected mice were rechallenged ~ 4 months after DaRT with 5 × 10⁶ CT26 tumor cells