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. 2019 Nov 25;10(12):883. doi: 10.1038/s41419-019-2123-y

Fig. 4. LINC01111 modulates the expression of several genes involved in cell proliferation, the cell cycle, cell invasion, and migration through SAPK/JNK signaling pathway in PC cells.

Fig. 4

a Western blotting showing protein expression involved in cell proliferation, the cell cycle, and metastasis in PC cells. b Hierarchical clustering analysis of microarray for PC cells (overexpressing LINC01111 and control cells) shows that LINC01111 could regulate genes involved in the SAPK/JNK signaling pathway. c Pathway enrichment analysis showing gene expression of subsets of genes related to the SAPK/JNK signaling pathway. d Western blotting showing the expression change of proteins involved in the SAPK/JNK signaling pathway. e Western blotting showing the abundance change of p-SAPK/JNK in the nucleus and the cytoplasm. f Representative confocal images showing the abundance change of p-SAPK/JNK in the nucleus and the cytoplasm.