Table 4.
The top 20 major bacterial composition of small intestine at species level. (%).
| vehicle | rabeprazole | vonoprazan | |||||
|---|---|---|---|---|---|---|---|
| % id | 5 mg/kg | 20 mg/kg | 5 mg/kg | 20 mg/kg | |||
| total_OTU00007 | Lactobacillus johnsonii | 100.0 | 18.20 ± 4.24 | 12.26 ± 2.00 | 8.43 ± 1.21* | 12.77 ± 3.45 | 10.03 ± 2.40+ |
| total_OTU00029 | Barnesiella intestinihominis | 86.5 | 13.34 ± 3.10 | 11.34 ± 2.08 | 11.33 ± 1.29 | 9.63 ± 2.19 | 13.90 ± 1.29 |
| total_OTU00016 | Lactobacillus intestinalis | 100.0 | 5.59 ± 1.00 | 11.54 ± 2.31* | 11.40 ± 0.82* | 17.61 ± 3.01** | 8.11 ± 1.60 |
| total_OTU00013 | Lactobacillus reuteri | 100.0 | 8.63 ± 1.29 | 11.95 ± 2.79 | 6.98 ± 0.66 | 8.26 ± 1.64 | 7.75 ± 1.96 |
| total_OTU00041 | Barnesiella intestinihominis | 88.6 | 7.69 ± 1.94 | 5.90 ± 0.95 | 6.75 ± 0.66 | 6.73 ± 1.57 | 5.63 ± 0.85 |
| total_OTU00024 | Lactobacillus murinus | 100.0 | 3.11 ± 1.04 | 8.44 ± 1.32* | 4.41 ± 0.52 | 5.06 ± 1.42 | 7.80 ± 2.93* |
| total_OTU00096 | Barnesiella intestinihominis | 86.9 | 4.05 ± 0.70 | 3.63 ± 0.70 | 3.96 ± 0.31 | 4.75 ± 0.73 | 5.09 ± 0.73 |
| total_OTU00129 | Porphyromonas HF001 | 86.0 | 3.49 ± 0.68 | 3.28 ± 0.61 | 2.53 ± 0.34 | 2.68 ± 0.63 | 3.48 ± 0.52 |
| total_OTU00116 | Porphyromonas catoniae | 88.1 | 2.37 ± 0.48 | 1.99 ± 0.46 | 3.03 ± 0.29 | 3.63 ± 0.91 | 3.28 ± 0.60 |
| total_OTU00097 | Porphyromonas catoniae | 86.0 | 2.40 ± 0.46 | 2.20 ± 0.37 | 1.86 ± 0.17 | 3.28 ± 0.82 | 2.42 ± 0.56 |
| total_OTU00188 | Barnesiella intestinihominis | 87.2 | 1.40 ± 0.34 | 1.65 ± 0.29 | 2.20 ± 0.22 | 1.68 ± 0.44 | 1.74 ± 0.43 |
| total_OTU00546 | Porphyromonas catoniae | 86.9 | 3.54 ± 0.69 | 0.86 ± 0.16** | 1.13 ± 0.09** | 1.98 ± 0.47** | 1.04 ± 0.24** |
| total_OTU00540 | Porphyromonas catoniae ATCC 51270 | 85.0 | 1.62 ± 0.31 | 1.46 ± 0.37 | 1.49 ± 0.15 | 1.72 ± 0.43 | 1.90 ± 0.50 |
| total_OTU00017 | Candidatus Arthromitus sp. SFB-mouse | 100.0 | 2.86 ± 0.86 | 0.86 ± 0.59 | 0.31 ± 0.15* | 2.33 ± 1.48 | 0.49 ± 0.32 |
| total_OTU00208 | Akkermansia muciniphila | 100.0 | 0.30 ± 0.06 | 1.74 ± 0.61* | 1.56 ± 0.26 | 1.18 ± 0.52 | 1.21 ± 0.56 |
| total_OTU00207 | Bacteroides sp. Tilapia9 | 84.1 | 1.04 ± 0.20 | 1.04 ± 0.30 | 1.17 ± 0.14 | 1.04 ± 0.25 | 1.08 ± 0.27 |
| total_OTU00127 | Clostridium disporicum | 99.5 | 1.75 ± 0.46 | 0.06 ± 0.03* | 0.01 ± 0.01* | 0.81 ± 0.27 | 2.21 ± 1.12 |
| total_OTU00276 | Eubacterium biforme DSM 3989 | 87.3 | 0.71 ± 0.19 | 0.72 ± 0.16 | 2.36 ± 0.26** | 0.00 ± 0.00** | 0.07 ± 0.02* |
| total_OTU00399 | Escherichia coli | 100.0 | 0.23 ± 0.13 | 0.05 ± 0.03 | 0.00 ± 0.00 | 0.94 ± 0.42 | 2.49 ± 2.47 |
| total_OTU00143 | [Bacillus] sp. KITNT-3 | 100.0 | 1.79 ± 1.20 | 0.05 ± 0.03* | 0.00 ± 0.00* | 0.84 ± 0.48 | 0.11 ± 0.07 |
Mean ± s.e. *p < 0.05 vs Vehicle, **p < 0.01 vs Vehicle, + P = 0.059.