Table 1.

TNBC and non-TNBC cell cisplatin IC₅₀ values in the presence and absence of the BAD pathway kinase inhibitors perifosine and H89. Drug IC₅₀ values were computed using GraphPad with Sigmoidal dose-response algorithm.

Cell line	Log IC50		Standard Error		P value
Cisplatin vs cisplatin + perifosine
	Perifosine	Perifosine	Perifosine	Perifosine
	0 μM	5 (or 20) μM	0 μM	5 (or 20) μM
Non-TNBC cells
MCF-7	1.2730	1.3610	0.0757	0.0545	0.3484
T47D	0.7591	0.8554	0.0450	0.0291	0.0845
TNBC cells
Hs578T	0.7096	0.7664	0.0245	0.0165	0.0592
MDA-157	0.6779	0.5646	0.0141	0.0116	<0.0001
MDA-231	1.0210	1.0110	0.0757	0.0545	0.3484
BT549	0.6101	0.4233	0.0301	0.0429	0.0009
MDA-436	−0.3877	NA	0.0413	NA	NA
MDA-468	0.6690	0.3878	0.0145	0.0199	<0.0001
Cisplatin vs cisplatin + H89
	H89 0 μM	H89 25 (or 12.5) μM	H89 0 μM	H89 25 (or 12.5) μM
Non-TNBC cells
MCF-7	1.1200	1.2110	0.0763	0.0488	0.3158
T47D	0.5374	1.1640	0.0344	0.1454	0.0008
TNBC cells
HS578T	0.9219	0.7339	0.0323	0.0483	0.0584
MDA-157	1.1180	0.7797	0.0275	0.0207	<0.0001
MDA-231	0.7749	0.8484	0.0817	0.0907	0.5525
BT549	0.9954	0.8362	0.0294	0.0356	0.0020
MDA-436	−0.2467	−0.3447	0.0385	0.0641	0.1936
MDA-468	0.6941	0.9348	0.1401	0.2755	0.4426