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. 2019 Nov 25;10(12):884. doi: 10.1038/s41419-019-2124-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Other studies have reported that miR-155-5p dysregulates intestinal epithelial Zo-1 by targeting RhoA. In addition, miR-155-5p regulates Th2 cytokines by inhibiting the expression of the PU.1 in the lung. In this study, upregulation of miR-155-5p directly targeting PKIα, which induces the disruption of TJ proteins, and then increases the expression of initiative key factors (TSLP, IL-33), promoted the release of type 2 cytokines and aggravated the allergic inflammation.