Table 1.
Micro-CT based evaluation of bone parameters in the scan group using different VOIS.
| Post-operative week | p-value# | Post-operative week | p-value# | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0–1 | 1–2 | 2–3 | 3–4 | 4–5 | 5–6 | 0 | 1 | 2 | 3 | 4 | 5 | 6 | |||||
| DC | BFR [%/day] | 0.23 ± 0.10* | 2.24 ± 1.20 | 2.40 ± 1.15 | 1.30 ± 0.49 | 0.63 ± 0.14 | 0.41 ± 0.09 | <0.0001 | BV/TV[%] | 1 ± 0 | 3 ± 1 | 17 ± 9* | 28 ± 15 | 30 ± 14 | 29 ± 12 | 28 ± 10 | <0.0001 |
| BRR [%/day] | 0.06 ± 0.02 | 0.14 ± 0.04* | 0.88 ± 0.36 | 1.06 ± 0.85 | 0.75 ± 0.43 | 0.52 ± 0.25 | <0.0001 | BV645/BV395 [%] | 1 ± 1 | 34 ± 10 | 26 ± 6 | 49 ± 7 | 67 ± 6 | 76 ± 6 | 80 ± 6 | <0.0001 | |
| DP | BFR [%/day] | 0.03 ± 0.02* | 0.38 ± 0.16 | 1.07 ± 0.88 | 0.68 ± 0.52 | 0.28 ± 0.20 | 0.18 ± 0.11 | <0.0001 | BV/TV [%] | 0 ± 0 | 0 ± 0 | 3 ± 1 | 9 ± 7 | 11 ± 9 | 11 ± 9 | 11 ± 8 | <0.0001 |
| BRR [%/day] | 0.01 ± 0.0 | 0.03 ± 0.02 | 0.19 ± 0.08 | 0.34 ± 0.31 | 0.30 ± 0.23 | 0.18 ± 0.16 | <0.0001 | BV645/BV395 [%] | 2 ± 3 | 24 ± 11 | 8 ± 2 | 37 ± 9 | 61 ± 10 | 71 ± 7 | 74 ± 9 | <0.0001 | |
| FC | BFR [%/day] | 0.22 ± 0.08 | 0.26 ± 0.15 | 0.31 ± 0.12 | 0.44 ± 0.19 | 0.45 ± 0.11 | 0.40 ± 0.12 | 0.0019 | BV/TV [%] | 57 ± 7 | 57 ± 6 | 53 + 6 | 48 ± 5 | 44 ± 5 | 41 ± 6 | 40 ± 7 | <0.0001 |
| BRR [%/day] | 0.24 ± 0.17* | 0.78 ± 0.31 | 1.13 ± 0.30 | 1.01 ± 0.30 | 0.80 ± 0.25 | 0.60 ± 0.21 | <0.0001 | BV645/BV395 [%] | 95 ± 1 | 92 ± 1 | 89 ± 2 | 87 ± 1 | 86 ± 2 | 86 ± 2 | 86 ± 3 | <0.0001 | |
| FP | BFR [%/day] | 0.43 ± 0.09* | 1.81 ± 0.58 | 1.77 ± 0.76 | 0.85 ± 0.41 | 0.51 ± 0.28 | 0.33 ± 0.20 | <0.0001 | BV/TV [%] | 5 ± 1 | 6 ± 1 | 16 ± 4 | 21 ± 7 | 20 ± 8 | 20 ± 9 | 20 ± 9 | <0.0001 |
| BRR [%/day] | 0.20 ± 0.09 | 0.40 ± 0.13* | 1.16 ± 0.30 | 0.90 ± 0.38 | 0.57 ± 0.22 | 0.35 ± 0.14 | <0.0001 | BV645/BV395 [%] | 0 ± 0 | 34 ± 9 | 23 ± 7 | 52 ± 7 | 69 ± 5 | 75 ± 4 | 78 ± 3 | <0.0001 | |
DC = defect center, DP = defect periphery, FC = cortical fragment center, FP = cortical fragment periphery; BFR – bone formation rate; BRR – bone resorption rate; BV/TV - bone volume normalized to DC for DC, DP and FC for FC, FP; BV645/BV395 - degree of bone mineralization given as ratio of bone volume with a density ≥ 645 mg HA/cm3 to the total osseous volume (threshold: 395 mg HA/cm3); *significant difference compared to subsequent week (p < 0.05); #p-value over time as tested with repeated measurements ANOVA with Bonferroni correction/Friedman test with Dunn correction for multiple comparisons, n = 10.