Table 2.
CT evaluation of bone parameters in the different volumes of interest (VOI) for the scan and control group.
| VOI | Parameter | Evaluation time point/period | Control group | Scan group |
|---|---|---|---|---|
| DC | BFR [%/day] | week 5–6 | 0.59 ± 0.24 | 0.41 ± 0.09 |
| BRR [%/day] | week 5–6 | 0.62 ± 0.28 | 0.52 ± 0.25 | |
| BV/TV [%] |
week 5 week 6 |
35 ± 11 35 ± 11 |
29 ± 12 28 ± 10 |
|
| BV645/BV395 [%] |
week 5 week 6 |
76 ± 2 80 ± 3 |
76 ± 6 80 ± 6 |
|
| DP | BFR [%/day] | week 5–6 | 0.18 ± 0.12 | 0.18 ± 0.11 |
| BRR [%/day] | week 5–6 | 0.15 ± 0.11 | 0.18 ± 0.16 | |
| BV/TV [%] |
week 5 week 6 |
11 ± 8 11 ± 8 |
11 ± 9 11 ± 8 |
|
| BV645/BV395 [%] |
week 5 week 6 |
71 ± 7 75 ± 6 |
71 ± 7 74 ± 9 |
|
| FC | BFR [%/day] | week 5–6 | 0.44 ± 0.19 | 0.40 ± 0.12 |
| BRR [%/day] | week 5–6 | 0.63 ± 0.19 | 0.60 ± 0.21 | |
| BV/TV [%] |
week 5 week 6 |
42 ± 6 41 ± 6 |
41 ± 6 40 ± 7 |
|
| BV645/BV395 [%] |
week 5 week 6 |
84 ± 3 84 ± 3 |
86 ± 2 86 ± 3 |
|
| FP | BFR [%/day] | week 5–6 | 0.32 ± 0.09 | 0.33 ± 0.20 |
| BRR [%/day] | week 5–6 | 0.30 ± 0.09 | 0.35 ± 0.14 | |
| BV/TV [%] |
week 5 week 6 |
21 ± 8 21 ± 8 |
20 ± 9 20 ± 9 |
|
| BV645/BV395 [%] |
week 5 week 6 |
76 ± 5 79 ± 4 |
75 + 4 78 + 3 |
DC – defect center; DP – defect periphery; FC – fragment center; FP – fragment periphery; BFR – bone formation rate; BRR – bone resorption rate; BV/TV - bone volume normalized to DC for DC, DP and FC for FC, FP. BV645/BV395 - degree of bone mineralization given as ratio of bone volume with a density ≥645 mg HA/cm3 to the total osseous volume (threshold: 395 mg HA/cm3). Control/scan group - n = 8/10; no significant differences were detected between the scan group and the control group (p ≥ 0.05), assessed by two-tailed Student’s t-test or Mann-Whitney U-test.