Figure 2.

Schematic representation showing the role of GATA4 in luteogenesis and luteolysis. Gata4 is located in the nucleus and regulates several steroidogenic enzymes gene expression. Although p62 is thought to be localized in the cytoplasm, recent studies have suggested that p62 physically interacts with nuclear proteins. Here, we show a hypothetical regulation of GATA4 transcription factor through an interaction with p62 in the luteolytic CL. STAR, Steroidogenic Acute Regulatory Protein; 3β-HSD, 3β-hydroxysteroid dehydrogenase; CYP11A, Cytochrome P450 Family 11 Subfamily A Member; Ub, Ubiquitin; LC3, Microtubule-associated protein 1A/1B-light chain 3; UBA, Ubiquitin-Associated domain.