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Schematic representation of the in vivo model. 8-week old male CD2F1 mice were exposed to i.p. cisplatin injections (C; 2.5 mg/kg), alone or in combination with zoledronic acid (ZA; 5 μg/kg), administered s.c. The control mice received equal volumes of sterile saline (V). The red arrows indicate the day of cisplatin treatment, whereas the purple arrows the day of ZA administration.
