Figure 2.

Cisplatin causes body weight loss and muscle depletion. Body weight curves (A), body weight change (i.e., body weight at time of sacrifice vs. initial body weight) (B), whole body grip strength (reported as peak force measured at day 7 and day 13) (C) and skeletal muscle weights (D) in mice exposed to cisplatin (n = 8). Control animals (V; n = 5) were administered equal volumes of sterile saline. Muscle weights were normalized to the Initial Body Weight (IBW) and expressed as weight/100 mg IBW. Data (means ± SEM) are expressed in grams. Significance of the differences: **p < 0.01, ***p < 0.001 vs. V.