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. 2019 Nov 25;9:17462. doi: 10.1038/s41598-019-53846-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Antimicrobial effect of tigecycline on intracellular MDRAB. Summarised results showing the survival rates of intracellular bacteria in J774A.1 cells and human macrophages treated with colistin (CST) and tigecycline (TGC). (a) Survival rates of ATCC 19606 (AB) and (b) a representative strain R1 in J774A.1 cells (24-hour culture) treated with CST and TGC at the concentrations indicated on the on the x axis. (c) Survival rates of AB and (d) a representative strain R1 in human macrophages (24-hour culture) treated with CST and TGC at the concentrations indicated on the on the x axis. Bar graphs represent the mean ± SEM; data are compiled from 2 independent experiments (n = 3 for each experiment). Asterisks indicate statistically significant differences (**P < 0.01; One-way ANOVA).