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. 2019 Nov 25;9(12):94. doi: 10.1038/s41408-019-0254-0

Fig. 5. In CoMMpass, +1q21 corresponds with poor prognosis.

Fig. 5

a Copy number alterations at the 1q21 locus in 870 myeloma samples from newly diagnosed patients in the CoMMpass study (IA13). Copy number is plotted as the log2 ratio of myeloma compared to normal from the same patient. Copy number thresholds are denoted by red lines and labeled (top). b Progression-free survival (PFS; left) and overall survival (OS; right) for patients with myeloma that has 2 × (gray; N = 575), 3 × (black; N = 242), and 4 × (red; N = 53) 1q21 copies. P-values indicate the difference in survival between 2×, 3×, and 4× 1q21 copies as determined using a Cox Proportional Hazards Wald test.