Table 2.

Univariate analysis.

Characteristic		N	Hazard ratio (95% CI)	HR P-value	Log-rank P-value
Age	≥65	114	0.79 (0.52–1.20)	0.264	0.262
	<65	87	Ref
Sex	Male	114	1.15 (0.75–1.76)	0.514	0.513
	Female	87	Ref
Race	African-American	55	0.89 (0.54–1.46)	0.644	0.743
	Caucasian	130	Ref
	Other/Unknown	16	0.73 (0.29–1.82)	0.504
Isotype	IgG	111	Ref		0.171
	IgA	46	1.12 (0.68–1.87)	0.654
	FLC	40	0.96 (0.55–1.68)	0.891
	Others	4	3.44 (1.06–11.14)	0.04
Hemoglobin	<10	65	1.27 (0.80–2.00)	0.311	0.309
	≥10	117	Ref
Platelets	<150	34	1.32 (0.74–2.36)	0.34	0.338
	≥150	129	Ref
Creatinine	>2.0	19	1.70 (0.87–3.31)	0.122	0.117
	≤2.0	155	Ref
Calcium	>10.5	16	3.29 (1.68–6.47)	<0.001	<0.001
	≤10.5	148	Ref
Albumin	<3.5	71	0.75 (0.46–1.22)	0.245	0.242
	≥3.5	102	Ref
LDH	<ULN	115	1.06 (0.26–4.38)	0.934	0.934
	≥ULN	8	Ref
β2M	>5.5	31	1.15 (0.66–2.00)	0.63	0.629
	≤5.5	137	Ref
M-spike	>3.0	71	0.92 (0.58–1.47)	0.741	0.741
	≤3.0	101	Ref
FLC Ratio	>100 or <0.001	88	1.48 (0.90–2.42)	0.122	0.119
	0.001 < k/l < 100	74	Ref
ISS	1	66	Ref		0.966
	2	68	1.00 (0.60–1.67)	0.995
	3	33	1.08 (0.59–1.98)	0.813
R-ISS	1	40	Ref		0.294
	2	75	1.27 (0.70–2.30)	0.44
	3	12	2.10 (0.82–5.39)	0.124
Upfront transplant	Yes	157	0.71 (0.41–1.24)	0.226	0.223
	No	44	Ref
Maintenance	Yes	155	0.49 (0.29–0.83)	0.008	0.007
	No	40	Ref
t(11;14)	Yes	35	0.86 (0.49–1.54)	0.619	0.618
	No	157	Ref
t(4;14)	Yes	9	2.45 (1.06–5.63)	0.035	0.029
	No	184	Ref
t(14;16)	Yes	9	2.77 (1.12–6.88)	0.028	0.022
	No	182	Ref
del(17p)	Yes	24	2.53 (1.40–4.59)	0.002	0.001
	No	173	Ref
del(13q)	Yes	84	1.71 (1.13–2.60)	0.011	0.01
	No	112	Ref
Hyperdiploidy	Yes	121	0.73 (0.47–1.15)	0.174	0.172
	No	69	Ref
del(1p)	Yes	21	1.27 (0.66–2.46)	0.473	0.472
	No	172	Ref
Complex Karyotype	Yes	44	2.05 (1.30–3.22)	0.002	0.002
	No	155	Ref
Gain(1q)	Yes	94	1.91 (1.26–2.91)	0.003	0.002
	No	107	Ref