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. 2019 Nov 25;10:5346. doi: 10.1038/s41467-019-13064-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Comparison of CATC-capsid-binding patterns in HHV-6B, MCMV, and HCMV. a A triangular facet of the HHV-6B icosahedral reconstruction. Four pU11nt subunits form a dimer-of-dimers, “VΛ”-shaped tetramer (cyan and orange red) atop triplexes Tb, Td, and Te, but absent from triplexes Ta, Tc (yellow), and Tf (blue). b The corresponding triangular facet in an MCMV icosahedral reconstruction⁹. Except for triplex Tc (yellow), two pM32nt subunits form a “Λ”-shaped dimer density (cyan and orange), with each of the two arms of the “Λ” holding to a neighboring hexon/penton capsomere like the cables of a cable-stayed bridge, and its vertex of the “Λ” sitting atop a triplex. c The corresponding triangular facet of an HCMV icosahedral reconstruction⁸. Three pUL32nt subunits form a “Δ”-shaped CATC densities atop every triplex. In all three panels, the density of pM32nt/pUL32nt and triplex in Tf region were colored in blue, as the densities in this region were smeared after imposing threefold symmetry during icosahedral reconstruction.