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. 2019 Nov 25;10:5351. doi: 10.1038/s41467-019-13259-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The HOXB-AS3 lncRNA regulates cell proliferation of AML cells. a Relative HOXB-AS3 RNA expression in OCI-AML3 cells treated with scramble versus anti-HOXB-AS3 gapmers (HOXB-AS3 KD). b Cell-cycle analysis in scramble versus anti-HOXB-AS3 gapmer-treated OCI-AML3 cells. Results of a representative experiment are shown. c Comparison of the percentages of cells at each stage of the cell cycle (G0/G1, S, and G2/M phases) in OCI-AML3 cells treated with scramble versus anti-HOXB-AS3 gapmers. Results of six independent experiments are shown. d Comparison of the numbers of colonies formed by scramble versus anti-HOXB-AS3 gapmer-treated OCI-AML3 cells in colony-forming unit assays. Results of three independent experiments are shown. e Relative HOXB-AS3 RNA expression in K-562 cells transfected with empty vector (control) versus a HOXB-AS3-overexpressing vector. f Cell-cycle in K-562 cells transfected with control versus HOXB-AS3-overexpressing vectors. Results of a representative experiment are shown. g Comparison of the percentages of cells at each stage of the cell cycle (G0/G1, S, and G2/M phases) in K-562 cells transfected with control versus a HOXB-AS3-overexpressing vectors. Results of three independent experiments are shown. P values were calculated using paired two-sided t-tests. In the figures, heights of boxplots indicate mean values with standard deviation. Error bars indicate highest and lowest values in each population. Source data are provided as a Source Data file.