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. 2019 Nov 25;10:5351. doi: 10.1038/s41467-019-13259-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Schematic depiction of the proposed functional role of HOXB-AS3 in NPM1mut AML. a Healthy state. NPM1 protein is in its wild-type configuration, resides in the nucleolus and regulates ribosome biogenesis. b NPM1 mutations lead to a reduction of the amount of NPM1 protein in the nucleolus and a reduction in the total amount of the transcribed rRNA. c NPM1 mutations also lead to aberrant upregulation of the HOXB-AS3 lncRNA. d HOXB-AS3 interacts with and guides EBP1 to the nucleolus. The increased amount of EBP1 interacts with the residual NPM1 and increases the output of transcribed rRNA.