Table 1.
Demographics and clinical characteristics of hepatocyte/liver cohorts
Hepatocyte Discovery Cohort | GTEx Liver Cohort | Innocenti Validation Liver Cohort | ||
---|---|---|---|---|
RNA-Seq cohort | Methylation cohort | |||
Variable | AA (n = 60) | AA (n = 44) | AA (n = 15) | AAa and EAb (n = 206) |
Percentage of AA subjects (%) | 100 | 100 | 100 | 11.1 |
Age, yearsc (mean ± SD) | 39 ± 20.5 | 46 ± 12.2 | 54.5 ± 6.6 | 46 ± 22 |
Sex (female %)d | 48.3 | 52.3 | 20 | 36.4 |
West Africane ancestry (%) (mean ± SD) | 78.17 ± 12.86 | 79.83 ± 11.86 | 84.04 ± 7.13 | NA |
aAA: African Americans >40% WAA
bEA: European Americans with <1% WAA
cp = 0.0280 for age (between groups, one-way ANOVA), p = 0.0409 (between RNA-Seq and GTEx Liver cohorts)
dp = 0.0439 for sex
ep = 0.2331 for ancestry