TABLE 2.
Respiratory parameters of VIACO mice.
| p6 | p127 | ||||
| CTRL n = 14 | VIACO n = 7 | CTRL n = 14 | VIACO n = 7 | Test parameter | |
| Respiratory rate [min–1] | 279.3 ± 35.1 | 291.3 ± 28.0 | 434.2 ± 80.8 | 424.4 ± 57.4 | PNT < 0.05; PEVT 0.133; FAge 58.669; PAge < 0.001; FGT 0.00339; PGT 0.954; Fint 0.338; Pint 0.564 |
| §0.654 | # < 0.001 | §0.713, # < 0.001 | |||
| CV interval | 0.19 ± 0.03 | 0.17 ± 0.02 | 0.49 ± 0.12 | 0.61 ± 0.13 | PNT < 0.05; PEVT < 0.05; FAge 162.62; PAge < 0.001; FGT 3.315; PGT 0.001; Fint 5.94; Pint 0.020 |
| §0.665 | # < 0.001 | §0.005, # < 0.001 | |||
| IrrScore Interval | 0.10 ± 0.02 | 0.10 ± 0.02 | 0.32 ± 0.05 | 0.42 ± 0.07 | PNT < 0.05; PEVT < 0.05; FAge 346.846; PAge < 0.001; FGT 11.377; PGT 0.002; Fint 11.326; Pint 0.002 |
| §0.996 | # < 0.001 | § < 0.001, # < 0.001 | |||
| Pause > 1s [min–1] | 0 ± 0 | 0 ± 0 | 0.10 ± 0.25 | 0.52 ± 0.53 | PNT < 0.05; PEVT < 0.05; FAge 13.721; PAge < 0.001; FGT 6.378; PGT 0.016; Fint 6.378; Pint 0.016 |
| §1.000 | #0.314 | § < 0.001, # < 0.001 | |||
| CV Amplitude | 0.41 ± 0.08 | 0.39 ± 0.07 | 0.26 ± 0.08 | 0.27 ± 0.07 | PNT < 0.05 PEVT < 0.05; FAge 31.713; PAge < 0.001; FGT 0.0808; PGT 0.778; Fint 0.374; Pint 0.544 |
| §0.530 | # < 0.001 | §0.818, #0.004 | |||
| IrrScore Amplitude | 0.24 ± 0.15 | 0.38 ± 0.53 | 0.25 ± 0.15 | 0.52 ± 0.75 | PNT < 0.05; PEVT = 0.349; FAge 0.337; PAge 0.565; FGT 2.670; PGT 0.111; Fint 0.224; Pint 0.639 |
| §n.t. | #n.t. | §n.t., #n.t. | |||
Data are shown as mean ± standard deviation (SD). Statistical analysis was performed with SigmaPlot 12.5 using two way ANOVA (General Linear Model; Degrees of Freedom: DFTotal 41) followed by Pairwise Multiple Comparison. PNT = P-value normality test; PEVT = P-value equal variance test; FAge = F-value for comparison of age, FGT = F-value for comparison of genotype; Fint = F-value for interaction; PAge = P-value for comparison of age; PGT = P-value for comparison of genotype; PInt = P-value for interaction. Pairwise Multiple Comparison were performed using the Holm-Sidak method. P-values for comparison between genotype per age categories are marked as “§.” P-values for comparison between age categories are marked as “#.” n: number of animals tested from each genotype and age group. Apneas (Pause > 1 s) are calculated per minute. n.t.: not tested.