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. 2019 Sep 11;73(11):1020–1025. doi: 10.1136/jech-2019-213055

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Monthly trends in hospitalisations for seizure in four study groups, for children <5 years of age in England, July 2000 to June 2017. Each analysis examines trends, including a comparison of observed incidence (black line) in England with expected incidence (red line) and associated 95% CIs (grey shaded area) in the absence of vaccination. Expected incidence and 95% CIs are based on predictions from regression models fitted to data for the period July 2000 to June 2013 for each outcome measure. The blue hashed line represents the introduction of rotavirus vaccine in the UK in July 2013, the green hashed line represents the introduction of the seven-valent pneumococcal conjugate vaccine (PCV7) in September 2006 and the yellow hashed line represents the replaced PCV7 with the 13-valent pneumococcal conjugate vaccine (PCV13) in the UK in April 2010. AGE, acute all-cause gastroenteritis.