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. 2019 Sep 11;73(11):1020–1025. doi: 10.1136/jech-2019-213055

Table 1.

Changes in rates of hospital admissions for febrile and all seizures in England

Age group (months) Mean yearly rate of hospital admission (per 10 000) Percentage reduction in hospital admissions post-vaccine introduction (95% CI)†
Pre-rotavirus vaccination Post-rotavirus vaccination (July 2013 to June 2017)
Observed Observed Expected* PCV7 PCV 13 RV
All seizures
 Hospital admissions for all seizures with any co-diagnosis
  <12 108.6 107.8 104.9 −2 (−8 to 3) 1 (-7 to 9) −4 (−8 to 0)
  12–23 180.7 144.8 153.1 5 (−1 to 11) 13 (5 to 21) 7 (2 to 12)
  24–59 75.2 71.8 75.1 1 (−7 to 8) 4 (−7 to 14) 4 (−2 to 9)
  0–59 103.2 93.3 97.7 2 (−5 to 7) 7 (−1 to 15) 4 (0 to 8)
 Hospital admissions for all seizures with AGE
  <12 3.7 2.6 3.9 −16 (−45 to 7) −12 (−59 to 22) 24 (7 to 39)
  12–23 8.5 5.6 9.8 −13 (−31 to 4) −12 (−41 to 12) 33 (20 to 44)
  24–59 2.1 2.1 2.6 −10 (−28 to 5) −7 (−33 to 15) 11 (−4 to 23)
  0–59 3.7 2.9 4.3 −13 (−30 to 2) −9 (−34 to 12) 23 (11 to 33)
 Hospital admissions for all seizures with pneumonia
  <12 3.4 2.8 2.3 −2 (−23 to 16) −9 (−46 to 19) −22 (−44 to −4)
  12–23 9.8 7 7 8 (−5 to 19) 0 (−21 to 18) 3 (−8 to 14)
  24–59 3.3 3.2 3.4 −3 (−17 to 10) −9 (−34 to 12) 2 (−11 to 13)
  0–59 4.6 3.9 3.9 1 (−9 to 11) −5 (−23 to 10) −1 (−10 to 8)
Febrile seizures
 Hospital admissions for febrile seizures with any co-diagnosis
  <12 36.4 25.8 27 13 (5 to 21) 20 (9 to 30) 10 (4 to 16)
  12–23 119.3 80.3 86.2 5 (−3 to 13) 16 (5 to 26) 8 (2 to 14)
  24–59 31.6 22.1 24 4 (−10 to 16) 12 (−7 to 27) 8 (−2 to 18)
  0–59 50.2 34.4 37.6 5 (−5 to 14) 15 (2 to 26) 10 (2 to 16)
 Hospital admissions for febrile seizures with AGE
  <12 1.7 0.9 1.5 −16 (−48 to 8) −6 (−55 to 27) 34 (16 to 48)
  12–23 4.7 2.2 4.1 −29 (−54 to −8) −22 (−59 to 7) 33 (19 to 45)
  24–59 0.8 0.5 0.7 −2 (−28 to 19) 15 (−20 to 39) 29 (12 to 43)
  0–59 1.8 0.9 1.6 −21 (−42 to −2) −8 (−38 to 16) 31 (19 to 41)
 Hospital admissions for febrile seizures with pneumonia
  <12 1.8 1.3 1.1 −17 (−50 to 9) −40 (−104 to 3) −27 (−59 to −1)
  12–23 7.5 4.7 4.6 7 (−8 to 19) −1 (−25 to 18) 1 (−13 to 13)
  24–59 1.7 1.2 1.2 9 (−10 to 25) 6 (−26 to 29) 8 (−8 to 22)
  0–59 2.9 1.9 1.9 3 (−10 to 15) −3 (−25 to 14) 1 (−10 to 11)

*Expected in the absence of rotavirus vaccination.

†Percentage change is calculated as 1−incidence rate ratio.

PCV7, seven-valent pneumococcal conjugate vaccine; PCV13, 13-valent pneumococcal conjugate vaccine; RV, rotavirus vaccine.