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. 2019 Nov 19;10:1224. doi: 10.3389/fneur.2019.01224

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Copyright © 2019 He, Yan, Qin, Zhang, Guo and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HIT-6 scores at different timepoints after baseline in patients with different degrees of RLS. (Left) HIT-6 scores at different timepoints after baseline in patients with moderate RLS; (Right) HIT-6 scores at different timepoints after baseline in patients with large RLS. **Indicates p < 0.001; *indicates p < 0.05. PFO, Patent foramen ovale; RLS, Right-to-left shunt.