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. 2019 Nov 19;9:1217. doi: 10.3389/fonc.2019.01217

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Copyright © 2019 Sweeney and Vyas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GvL and GvHD T cell responses. Separation of GvL from GvHD T cell responses according to tissue expression of immunogenic MHC-binding peptides. Peptides may result from germline differences between donor and recipient (minor histocompatibility antigens), somatic mutations (neoantigens), or overexpression of non-mutant peptides that are not expressed by healthy tissues (leukemia-associated antigens). AML, acute myeloid leukemia; MHC, major histocompatibility complex; TCR, T cell receptor; GvL, graft-versus-leukemia; GvHD, graft-versus-host disease. Created with BioRender.com.