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. 2019 Nov 19;9:1241. doi: 10.3389/fonc.2019.01241

Table 2.

Comparison of single-slice and whole-lesion histogram parameters of PM and NM in the training and validation datasets.

Parameters Training dataset Validation dataset
NM PM p NM PM p
S-ASD −2.976 ± 15.859 −2.902 ± 8.077 0.973 −2.312 ± 9.593 0.490 ± 6.293 0.181
S-STD 161.602 ± 101.977 135.420 ± 60.213 0.076 129.270 ± 68.500 130.685 ± 59.258 0.932
S-Average ratio 0.428 ± 0.685 1.345 ± 1.414 <0.001* 0.523 ± 0.888 0.993 ± 0.887 0.045*
S-Mean −58.878 ± 340.285 −15.669 ± 330.362 0.456 −73.787 ± 164.636 −37.878 ± 88.316 0.289
S-Skewness 0.088 ± 1.089 −0.854 ± 0.816 <0.001* 0.231 ± 1.035 −0.871 ± 0.995 <0.001*
S-Kurtosis 0.987 ± 4.616 1.163 ± 3.397 0.802 1.364 ± 3.860 1.727 ± 5.520 0.772
S-Area 0.775 ± 0.357 1.236 ± 0.416 <0.001* 0.795 ± 0.419 1.128 ± 0.373 0.002*
S-Volume 0.428 ± 0.685 1.345 ± 1.414 <0.001* 0.523 ± 0.888 0.993 ± 0.887 0.045*
S-Median −50.810 ± 344.826 −73.250 ± 146.112 <0.001* −299.820 ± 296.139 −29.190 ± 114.492 <0.001*
S-Maximum 190.590 ± 450.767 156.170 ± 176.689 0.57 123.320 ± 600.592 197.130 ± 112.848 0.498
S-Minimum −58.970 ± 233.980 −69.970 ± 252.732 0.035* −623.040 ± 210.656 −532.810 ± 289.115 0.178
W-ASD 364.124 ± 909.629 218.649 ± 176.266 0.214 211.019 ± 314.358 204.203 ± 179.826 0.917
W-STD 161.978 ± 101.572 135.300 ± 60.134 0.07 128.909 ± 68.194 130.383 ± 59.421 0.929
W-Average ratio 0.960 ± 0.466 1.610 ± 0.522 <0.001* 0.960 ± 0.404 1.485 ± 0.450 <0.001*
W-Mean −39.095 ± 326.163 −99.504 ± 129.099 0.002* −292.437 ± 290.740 −56.853 ± 106.652 <0.001*
W-Skewness 0.064 ± 1.016 −0.851 ± 0.824 <0.001* 0.245 ± 1.041 −0.859 ± 1.008 <0.001*
W-Kurtosis 3.723 ± 4.279 4.185 ± 3.455 0.494 4.373 ± 3.957 4.713 ± 5.622 0.791
W-Area 86.586 ± 145.308 206.406 ± 221.798 <0.001* 93.797 ± 112.534 167.841 ± 189.459 0.076
W-Volume 134.501 ± 340.853 394.708 ± 510.214 0.001* 122.925 ± 184.577 301.584 ± 380.789 0.028*
W-Median −42.164 ± 337.581 −73.365 ± 146.188 <0.001* −299.839 ± 295.991 −29.359 ± 114.730 <0.001*
W-Maximum 188.810 ± 450.066 156.140 ± 176.460 0.589 138.640 ± 586.255 195.940 ± 110.947 0.59
W-Minimum −18.330 ± 250.784 −57.700 ± 263.027 0.172 −613.680 ± 225.487 −505.530 ± 311.857 0.134

ASD, Average standard deviation ratio; STD, Standard deviation.

S-, single-slice histogram parameters; W-, whole-lesion histogram parameters. A two-sample t-test was used to compare the differences of those parameters.

*

p < 0.05.