Table 3.
Adverse events after transplantation of limbal stem cells
| Variable | Autologous cultured LSC transplantation (autoLSC group) | Allogeneic cultured LSC transplantation (alloLSC group) | Autologous limbal tissue transplantation (autoLT group) | Allogeneic limbal tissue transplantation (alloLT group) |
|---|---|---|---|---|
| Total no. of adverse events | 2 | 40 | 16 | 45 |
| No. of eyes with at least one adverse event | 1/7 | 7/7 | 6/8 | 8/8 |
| Phthisis bulbi | 0 | 1 | 1 | 1 |
| Corneal perforation requiring transplantation | 0 | 4 | 0 | 4 |
| Herpes keratitis requiring transplantation | 0 | 1 | 0 | 0 |
| Bacterial keratitis requiring transplantation | 0 | 3 | 0 | 0 |
| Bacterial keratitis treated medically | 0 | 3 | 0 | 3 |
| Fungal keratitis treated medically | 0 | 0 | 0 | 1 |
| Epithelial defect requiring AMT and/or tarsorrhaphy | 0 | 6 | 0 | 5 |
| Epithelial defect treated topically | 2 | 11 | 4 | 15 |
| Superficial punctate keratitis | 0 | 2 | 0 | 0 |
| Corneal transplantation rejection | 0 | 3 | 5 | 6 |
| Retinal detachment | 0 | 0 | 0 | 1 |
| Acute retinal necrosis | 0 | 0 | 0 | 1 |
| Vitreous hemorrhage | 0 | 0 | 0 | 1 |
| Epiretinal membrane | 0 | 0 | 0 | 1 |
| Cataract requiring surgery | 0 | 2 | 2 | 3 |
| Elevated IOP | 0 | 3 | 2 | 0 |
| Symblepharon | 0 | 0 | 0 | 2 |
| Trichiasis | 0 | 0 | 1 | 1 |
| Lagophthalmos | 0 | 0 | 1 | 0 |
| Quinolone‐related tendinopathy | 0 | 1 | 0 | 0 |
Shown are the number of adverse events that occurred (i.e., one eye may experience the same adverse event several times).
Abbreviations: AMT, amniotic membrane transplantation; IOP, intraocular pressure; LSC, limbal stem cell.