Figure 3.

The effect of oestradiol on dopamine release after cocaine is mediated by ERβ. DPN‐treated females show significantly greater dopamine release after cocaine administration during (A) 20 Hz 24p stimulation of the VTA but not (B) 20 Hz 12p, (C) 10 Hz 24p or (D) 10 Hz 12p stimulation. Bars show mean (+SEM) % change in [DAc] after i.p. administration of 10 mg·kg⁻¹ cocaine HCl. Individual subject values are also shown. 20 Hz 24p: n = 6 for DPN‐treated females; n = 7 for vehicle‐treated females, vehicle‐treated males and DPN‐treated males; and n = 8 for PPT‐treated females and PPT‐treated males. 20 Hz 12p: n = 6 for DPN‐treated females; n = 7 for vehicle‐treated females, vehicle‐treated males and DPN‐treated males; and n = 8 for PPT‐treated females and PPT‐treated males. 10 Hz 24p: n = 6 for vehicle‐treated females, DPN‐treated females and vehicle‐treated males; n = 7 for DPN‐treated males; and n = 8 for PPT‐treated females and PPT‐treated males. 10 Hz 12p: n = 4 for DPN‐treated females; n = 5 for vehicle‐treated males; n = 6 for vehicle‐treated females and DPN‐treated males; and n = 8 for PPT‐treated females and PPT‐treated males. *P < 0.05, significantly different, within sex, from vehicle. ^# P < 0.05, significantly different between sexes.