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IL-6 in ADSCs promoted flap recovery through the increased cell proliferation in IL-6 KO mice. (a) Representative photographs of skin flaps with or without ADSC treatment on postoperative day 5 of I/R in IL-6 KO mice. (b) Flap sections were immunostained with anti-PCNA antibody. Bar = 400 μm. (c) The rectangles in (b) are magnified and shown in (c). Bar = 100 μm. (d) Histogram showing the number of proliferating cell under HPF. ∗p < 0.05 versus the IL-6 KO I/R group.
