Table 2.
Association between clinicopathological factors and changes in FA scores.
| FA score decreased or unchanged (n = 84) | FA score increased (n = 22) | P | |
|---|---|---|---|
| Age (years) | 0.017 | ||
| ≤60 | 47 | 6 | |
| >60 | 37 | 16 | |
| Sex | 0.219 | ||
| Female | 23 | 9 | |
| Male | 61 | 13 | |
| Distance from anal verge (cm) | 0.436 | ||
| ≤5 | 46 | 10 | |
| >5 | 38 | 12 | |
| Pathologic differentiation | 0.938 | ||
| Well, moderately | 72 | 19 | |
| Poorly, mucinous | 12 | 3 | |
| CEA (ng/ml) | 0.872 | ||
| ≤5 | 55 | 14 | |
| >5 | 29 | 8 | |
| CA19-9 (ng/ml) | 0.112 | ||
| ≤37 | 70 | 15 | |
| >37 | 14 | 7 | |
| Pathologic T stage | 0.766 | ||
| T0-2 | 60 | 15 | |
| T3-4 | 24 | 7 | |
| Pathologic N stage | 0.825 | ||
| N0 | 63 | 17 | |
| N+ | 21 | 5 | |
| LVI | 0.073 | ||
| Negative | 74 | 16 | |
| Positive | 10 | 6 | |
| PNI | 0.730 | ||
| Negative | 70 | 19 | |
| Positive | 14 | 3 | |
| pCR | 0.303 | ||
| Yes | 20 | 3 | |
| No | 64 | 19 | |
| Downstage | 0.971 | ||
| Yes | 50 | 13 | |
| No | 34 | 9 | |
| Pre-CRT Fib | 3.38 ± 0.98 | 3.72 ± 0.63 | 0.051∗ |
| Post-CRT Fib | 3.27 ± 0.74 | 4.33 ± 1.13 | ≤0.001∗ |
| Pre-CRT Alb | 40.73 ± 4.45 | 40.27 ± 3.31 | 0.649∗ |
| Post-CRT Alb | 40.92 ± 4.04 | 36.60 ± 5.75 | 0.003∗ |
pCR: pathologic complete response; CEA: carcinoembryonic antigen; CA19-9: carbohydrate antigen 19-9; CRT: chemoradiotherapy; LVI: lymph vascular invasion; PNI: perineural invasion; Fib: fibrinogen; Alb: albumin; FA: fibrinogen and albumin. ∗Independent t-tests were used to analyze with continuous variables.