Table 1.
Main characteristics of the included studies.
| Study (authors-year) | Region | Sample size | Hepatitis type | Follow-up period (years) | No. of HCC (%) | Cut-off value | APRI high (%) | Analysis method | HR estimation (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| Pretreatment | |||||||||
| Song BG (2018) | Korea | 1014 | CHB | Median 3.9 | 37 (3.6) | 0.5 | 270 (26.6) | M | 2.57 (1.31-5.02) |
| Paik N (2018) | Korea | 1006 | CHB | Median 5.1 | 36 (3.6) | 0.5 | 219 (21.7) | M | 6.10 (2.74-13.50) |
| Chang KC (2018) | Taiwan | 800 | CHC | Median 4.46 | 100 (12.5) | 2.57 | 155 (19.4) | M | 2.31 (1.44-3.68) |
| Kim JH (2018) | Korea | 924 | ALC | Median 4.83 | 83 (9.0) | 1 | 120 (13.0) | M | 1.46 (0.73-2.94) |
| Nishikawa H (2017) | Japan | 338 | CHB | Median 4.99 | 33 (9.8) | 0.786 | 188 (55.6) | M | 1.13 (0.34-3.71) |
| Ji FP (2017) | China | 34 | CHC | Median 3.45 | 5 (14.7) | 2.5 | 12 (35.3) | U | 2.08 (1.03-4.21) |
| Kim JH (2016) | Korea | 542 | CHB | Until Sept. 2012 | 68 (12.5) | 0.766 | 214 (39.5) | U | 6.20 (3.32-11.58) |
| Lee K (2016) | Korea | 598 | CHC | Median 5.1 | 8 (1.3) | 1.0 | 21 (3.5) | U | 1.44 (1.16-1.80) |
| Wu CK (2016) | Taiwan | 1351 | CHC | Until July 2014 | 49(3.6) | 0.7 | 1000 (10.0) | U | 4.85 (1.51-15.60) |
| Ng KJ (2016) | Taiwan | 105 | CHC | Mean 4.38 | 15 (14.3) | 2 | 52 (49.5) | M | 5.55 (1.19-25.86) |
| Hann HW (2015) | USA | 686 | CHB | Median 4.37 | 60 (8.7) | Median | 344 (50.1) | M | 2.04 (1.10-3.79) |
| Posttreatment | |||||||||
| Ji FP (2017) | China | 34 | CHC | Median 3.45 | 5 (14.7) | 1.5 | 13 (38.2) | U | 2.69 (1.35-5.38) |
| Wu CK (2016) | Taiwan | 1351 | CHC | Until July 2014 | 49(3.6) | 0.7 | 135 (10.0) | M | 2.94 (1.51-5.74) |
| Chen TM (non-SVR) (2016) | Taiwan | 183 | CHC | Median 3.07 | 14 (7.7) | 1.5 | 45 (24.6) | M | 10.91 (2.49-47.70) |
| Chen TM (SVR) (2016) | Taiwan | 540 | CHC | Median 3.45 | 15 (2.8) | 0.5 | 121 (22.4) | M | 4.40 (1.46-13.23) |
| Yu ML (2006) | Taiwan | 776 | CHC | Mean 4.75 | 41 (5.3) | 0.75 | 176 (22.7) | M | 5.78 (2.31-14.45) |
CHB: chronic hepatitis B; CHC: chronic hepatitis C; ALC: alcoholic liver cirrhosis; M: multivariate; U: univariate; SVR: sustained virologic response; non-SVR: nonsustained virologic response.