Table 2.
Genotype and allele frequencies in different psoriatic disease groups and controls.
| Controls, N = 550 | Total PD, N = 690 | PsA, N = 187 | PCP, N = 309 | p value, OR (95% CI) | |
|---|---|---|---|---|---|
| NFKB1 rs230526 A/G | AA vs. AG + GG | ||||
| AA | 77 (0.14) | 108 (0.16) | 30 (0.16) | 42 (0.14) | p=0.45 |
| AG | 264 (0.48) | 359 (0.52) | 95 (0.51) | 164 (0.53) | OR = 1.21 |
| GG | 209 (0.38) | 223 (0.32) | 62 (0.33) | 103 (0.33) | 0.73–2.02 |
|
| |||||
| NFKBIA rs7152376 T/C | CC + CT vs. TT | ||||
| TT | 231 (0.42) | 291 (0.42) | 64 (0.34) | 147 (0.48) | p=0.004 |
| TC | 242 (0.44) | 314 (0.46) | 89 (0.48) | 133 (0.43) | OR = 1.74 |
| CC | 77 (0.14) | 85 (0.12) | 34 (0.18) | 29 (0.09) | 1.20–2.54 |
|
| |||||
| NFKBIZ rs3217713 indel | Del/Del vs. Ins/Ins + Ins/Del | ||||
| INS/INS | 336 (0.61) | 451 (0.65) | 124 (0.66) | 210 (0.68) | p=0.06 |
| INS/DEL | 193 (80.35) | 207 (0.30) | 51 (0.27) | 90 (0.29) | OR = 2.29 |
| DEL/DEL | 21 (0.04) | 32 (0.05) | 12 (0.06) | 9 (0.03) | 0.94–5.53 |
p and OR values correspond to the putative PsA risk vs. non‐risk genotypes. PD: psoriatic disease; PsA: psoriatic arthritis; PCP: pure cutaneous psoriasis (absence of arthritis after 10 or more years of psoriasis onset); OR: odds ratio; CI: confidence interval.