Table 1-.
Characteristics of participants across TDP-43 stages (n=293)
| TDP-43 Stages | ||||
|---|---|---|---|---|
| Stage 0, n=150 | Stage 1, n=58 | Stage 2, n=45 | Stage 3, n=40 | |
| Demographics | ||||
| Age-at-death, y, mean (SD) | 89.5 (6.50) | 91.3 (6.17) | 93.0 (4.75 | 101.6 (4.11) |
| Female, n % | 103 (68.7%) | 43 (74.1%) | 31 (68.9%) | 37 (92.5%) |
| Education, y, mean (SD) | 15.4 (3.37) | 18.8 (3.14) | 14.8 (2.92) | 15.6 (2.61) |
| Clinical (proximate-to-death) | ||||
| Literacy score, mean (SD) | 60.5 (17.93) | 53.1 (17.70) | 52.36 (15.40) | 43.1 (13.35) |
| MMSE score, mean (SD) | 24.0 (6.96) | 22.2 (8.22) | 22.05 (6.95) | 16.6 (9.51) |
| Global cognition, mean (SD) | −0.5 (1.07) | −0.7 (1.05) | −0.9 (1.04) | −1.5 (1.01) |
| Pathologic | ||||
| AD pathology score, mean (SD) | 0.6 (1.07) | 0.8 (0.62) | 0.7 (0.49) | 1.09 (0.59) |
| NIA-Reagan, n (%) | 90 (60%) | 40 (69.0%) | 32 (71.1%) | 36 (90.0%) |
Abbreviations: y – Years; SD – Standard deviation, MMSE – Mini-Mental-State-Examination; AD – Alzheimer’s disease; TDP-43 – Transactive response DNA-Binding Protein 43