Table 2.
Baseline demographic and clinical characteristics of study population
| All dose levels N=34 |
Dose 1 (0.125 mg/kg/day) N=6 |
Dose 2 (0.25 mg/kg/day) N=7 |
Dose 3 (0.5 mg/kg/day) N=3 |
Dose 4 (0.75 mg/kg/day) N=18 |
P value (across doses) |
|
|---|---|---|---|---|---|---|
| Age, y* | 4 (2.1–16.5) | 7.3 (2.5-12.8) | 3.3 (2.2-16.5) | 5.3 (3.9-11.9) | 3 (2.1-14.5) | 0.19 |
| Males, N (%) | 24 (70.6) | 2 (33.3) | 5 (71.4) | 3 (100) | 14 (77.8) | 0.18 |
| Race, N (%) | ||||||
| White | 21 (61.8) | 1 (16.7) | 5 (71.4) | 1 (33.3) | 14 (77.8) | 0.01 |
| Asian | 3 (8.8) | 0 (0) | 0 (0) | 2 (66.7) | 1 (5.6) | |
| African American | 1 (2.9) | 1 (16.7) | 0 (0) | 0 (0) | 0 (0) | |
| Other† | 1 (2.9) | 1 (16.7) | 0 (0) | 0 (0) | 0 (0) | |
| More than one | 8 (23.5) | 3 (50) | 2 (28.6) | 0 (0) | 3 (16.7) | |
| Hispanic ethnicity, N (%) | 13 (38.2) | 1 (16.7) | 4 (57.1) | 1 (33.3) | 7 (38.9) | 0.62 |
| Days of illness at study enrollment*^ | 8 (4-21) | 8 (4-17) | 10 (4-21) | 7 (5-9) | 7.5 (5-15) | 0.62 |
| White blood | ||||||
| cell count, ×109/L* | 12.9 (4.7-36.7) | 11.9 (6-26.7) | 14.2 (8.7-36.7) | 12 (6.2-16.8) | 13.6 (4.7-23.5) | 0.72 |
| zHgb, *‡ | −1.6 (−3.8 to 2.67) | −1.3 (−3.5 to 1.2) | −2.6 (−3.8 to −0.8) | −2.7 (−2.8 to −1.7) | −1.3 (−3.7 to 2.7) | 0.14 |
| Platelet count, ×109/L* | 356 (66-624) | 385 (184-624) | 389 (308-550) | 283 (201-429) | 346 (66-554) | 0.56 |
| CRP, mg/dL* | 8.8 (0.5-36.3) | 6.5 (0.5-21.7) | 17.2 (4-36.3) | 17.7 (6.9-25.9) | 8.6 (3.5-31.7) | 0.38 |
| ESR, mm/hr* | 68 (10->140) | 60 (38-72) | 80 (37->140) | 99 (45->140) | 69 (10->140) | 0.40 |
| ALT, U/L* | 62 (15-473) | 55 (19-191) | 49 (19-268) | 62 (25-166) | 68 (15-473ss) | 0.81 |
| GGT, U/L* | 62 (11-270) | 128 (16-211) | 84 (13-270) | 95 (25-136) | 31 (11-249) | 0.58 |
| Albumin, g/dL* | 3.5 (2.4-5.9) | 3.5 (3.3-5.9) | 3.6 (2.9-4.2) | 3.5 (3.3-3.8) | 3.6 (2.4-4.4) | 0.97 |
| Z scores*§ Proximal LAD | 2.7 (0.4-9.1) | 2.6 (0.6-4.2) | 5.2 (0.4-9.1) | 3.3 (3.2-3.5) | 2.5 (1.4-6.2) | 0.36 |
| Proximal RCA | 2.3 (−0.7-8.9) | 2.4 (0.8-3.7) | 2.7 (0.8-8.9) | 3.3 (2.4-4.1) | 1.9 (−0.7-5.3) | 0.30 |
*
Median (Range)
†
Other: Afghani
^
One subject was enrolled on day 21 of illness rather than within the first 20 days of illness
‡
zHgb, standard deviation units from the mean for age-adjusted hemoglobin values1
§
LAD, left anterior descending coronary artery; RCA, right coronary artery; Z scores were calculated as previously published2
[1]
Gunn L, Nechyba C. The Harriet Lane Handbook:16th edition. Philadelphia: Mosby; 2002.
[2]
de Zorzi A, Colan SD, Gauvreau K, Baker AL, Sundel RP, Newburger JW. Coronary artery dimensions may be misclassified as normal in Kawasaki disease. J Pediatr. 1998;133:254-8.