Table 7; online.
Comparison of z max and change in Z score for the study population over time by dose level*
| Overall | Dose 1 (0.125 mg/kg) N= 6 |
Dose 2 (0.25 mg/kg) N= 7 |
Dose 3 (0.5 mg/kg) N= 3 |
Dose 4 (0.75 mg/kg) N= 18 |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Zmax† | 2.9 (2.5 to 3.6) | 3 (2.9 to 3.5) | 5.2 (2.5 to 8.6) | 3.5 (3.3 to 3.8) | 2.6 (2.5 to 3.1) | |||||
| 2 week Z score minus baseline |
6 week Z score minus baseline |
2 week Z score minus baseline |
6 week Z score minus baseline |
2 week Z score minus baseline |
6 week Z score minus baseline |
2 week Z score minus baseline |
6 week Z score minus baseline |
2 week Z score minus baseline |
6 week Z score minus baseline |
|
| LAD‡ | −0.9 (−1.4 to 0.3) | −1.2 (−1.5 to −0.2) | −1 (−1.5 to 0.2) | −1.5 (−1.8 to −1.3) | 0 (−1 to 0.3) | −0.1 (−1 to 0.4) | −1.4 (−2 to −1.1) | −1.7 (−2.2 to −1.4) | −0.8 (−1.2 to 0.2) | −1.2 (−1.2 to −0.6) |
| RCA‡ | −0.7 (−1.5 to 0) | −1.1 (−1.8 to −0.4) | −0.9 (−1.4 to −0.7) | −1.4 (−1.8 to −1.3) | −0.6 (−1.2 to −0.2) | −0.8 (−1.0 to 0.1) | −0.6 (−0.9 to −0.3) | −2.2 (−2.4 to −1.9) | −0.5 (−1.4 to 0.4) | −0.9 (−1.6 to −0.3) |
*
Median (IQR)
‡
LAD, left anterior descending coronary artery; RCA, right coronary artery. z scores were calculated as previously published 1
†
Zmax is the largest Z score of either the LAD or RCA over the 6 week course of therapy