Figure 2.
Plasma and brain concentrations of nicotine (panels A and B, respectively) and cotinine (panels C and D, respectively) following s.c. injection of 0.75 mg/kg (training dose) nicotine (unfilled bars) and aerosolized 30 mg/ml freebase nicotine (shaded bars) in adult male and female C57BL/6 mice. Each bar represents the mean (± SEM) of data for 6 mice. * indicates significant (p<0.05) main effect of sex. # indicates significant (p<0.05) main effect of route of administration.