Table 3:
Algorithm’s Diagnostic Performance for Individual Vessel Segments
| No. occlusions (%) No. controls |
AUC†
(95% CI) |
Target Sens (%) (95%CI in %) |
Target Spec (%) (95%CI in %) |
Threshold (range) ‘COLOR’ |
Jmax Sensitivity (%) (95%CI in %) |
Jmax Specificity (%) (95%CI in %) |
Jmax
(95%CI) (threshold range) ‘COLOR’ |
|
|---|---|---|---|---|---|---|---|---|
|
Intracranial
ICA incl. terminal ICA |
133 (20.03) 531 |
0.977 (0.965–0.989) |
129/133 (96.99) 92.5–99.2 |
459/531 (86.44) 83.2–89.2 |
<60%–45% YELLOW |
118/133 (88.72) 82.1–93.5 |
521/531 (98.12) 96.6–99.1 |
0.8684 0.8174–0.9153 <45% RED |
| M1-MCA | 290 (35.32) 531 |
0.962 (0.948–0.976) |
281/290 (96.90) 94.2–98.6 |
423/531 (79.66) 76.0–83.0 |
<75%–60% GREEN |
243/290 (83.79) 79.0–87.8 |
521/531 (98.12) 96.6–99.1 |
0.8191 0.7724–0.8494 <45% RED |
| M2-MCA | 60 (10.15) 531 |
0.874 (0.826–0.921) |
54/60 (90.00)* 79.5–96.2 |
398/531 (74.95) 71.0–78.6 |
<80%–75% BLUE |
52/60 (86.67) 75.4–94.1 |
423/531 (79.66) 76.0–83.0 |
0.6633 0.5479–0.7327 <75%–60% GREEN |
Note. – ‘Target Sens’ is associated with ‘Threshold’ that yields ≥95% sensitivity at the highest specificity (‘Target Spec’).
Jmax is the maximum Youden index (sensitivity + specifity − 1) across all thresholds.
†
The DeLong algorithm was used to compute the Standard Error of the AUC.
*
For M2-MCA segments the ≥95% sensitivity target could not be met.