Figure 2.

Different methods for estimating CST injury. There are a variety of methods for calculating CST injury from a given stroke lesion and CST template. (A) One method uses area overlap between the stroke lesion and binarized CST tract on the axial slice with maximal overlap. Left panel shows coronal binarized CST tract, middle shows axial slice with maximal overlap between stroke and CST, right shows zoomed overlap of stroke (red) and CST template (blue). The # of voxels overlapped (red-blue overlay) are divided by the total # of blue voxels. (B) In calculating 3D volume overlap between stroke (red) and CST (blue), raw- and weighted- values are incorporated into CST weighting to account for the probabilistic nature of the CST and narrowing of the CST at different points (i.e. the posterior limb of the internal capsule). Left panel shows probabilistic nature of CST in a coronal slice. Middle panel highlights the weighted nature of the tract with purple to light blue colorbar. The horizontal lines indicate corresponding axial slices of the CST that are shown in the right panel. (C) Another method divides the CST into a number of rostral-caudal strands (16 in this case) and calculates % injury to each strand. If any given strand is lesioned by more than 5%, the strand is classified as injured. The right, middle, and left panels show coronal, sagittal, and axial slices respectively with CST strands in different colors (gray-blue gradient) and with stroke lesion shown in red.