Figure 1.

FGFR pathway.

FGFRs dimerize upon ligand building and trigger a downstream cascade of signaling pathways. Mutation, translocation, gene amplification, and also an increase in circulating FGF ligands, can active FGFR receptors. Downstream signaling can trigger the PI3K/Akt pathway, the MAPK pathway, phosphorylation of the STAT, resulting in DNA transcription.

FGF, fibroblast growth factor; FGFR, fibroblast growth factor receptor; MAPK, mitogen activated protein kinase; PI3K/Akt, phosphoinositide-3-kinase; STAT, signal transducer and activator of transcription.