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. 2019 Nov 24;15:1744806919880643. doi: 10.1177/1744806919880643

Figure 1.

Figure 1.

Effects of APPL1 on the formation of dendritic spine and synapse in STZ-induced diabetic rats. (a) to (c) The immunofluorescent staining for Map2 in control rats, PDN rats, APPL1-deficient PDN rats, and APPL1-overexpressed PDN rats. (d) to (f) The immunofluorescent staining for Bassoon in control rats, PDN rats, APPL1-deficient PDN rats, and APPL1-overexpressed PDN rats. The abbreviations for the groups of normal control (CON), CON + shRNA recombinant lentiviral vector, painful diabetic neuropathy + vacant lentiviral vector (PDN), PDN + shRNA recombinant lentiviral vector and PDN + APPL1 overexpression recombinant lentiviral vector are shown as CON, CON + shRNA, PDN, PDN + shRNA and PDN + OXP. (n = 20, *P <0.05 vs. control group). Data are expressed as the means ± SEM.