Table 2.
Main clinicopathological characteristics of all relevant studies
| First author (Ref.) | T2DM without DPN | T2DM with DPN | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N (M/F) | Age (yrs.) | LDL (mmol/L) | SBP (mmHg) | P-value* | N (M/F) | Age (yrs.) | LDL (mmol/L) | SBP (mmHg) | P-value** | |
| Zhao W. et al. [4] | 365 (230/135) | 59.48 | 2.75 ± 0.86 | 130.29 ± 15.93 | 0.01 | 104 (53/51) | 66.94 | 2.62 ± 0.82 | 135.81 ± 17.65 | 0.133 |
| Wu F. et al. [5] | 560 (338/222) | 53.20 | 2.84 ± 0.96 | 129.10 ± 17.30 | <0.01 | 574 (307/267) | 61.00 | 2.66 ± 0.95 | 134.4 ± 18.40 | 0.002 |
| ALMA R. et al. [6] | 12 (6/6) | 53.60 | 2.20 ± 0.70 | NA | NA | 70 (46/24) | 60.23 | 2.30 ± 1.25 | NA | NA |
| Yang J. et al. [7] | 1287 (626/661) | 58.61 | 2.78 ± 1.01 | 132.06 ± 20.54 | 0.03 | 224 (117/107) | 66.58 | 2.75 ± 0.99 | 134.72 ± 22.25 | 0.438 |
| Bilir B. et al. [8] | 53 (24/29) | 58.85 | 3.59 ± 1.40 | 128.97 ± 11.73 | NA | 46 (23/23) | 56.91 | 3.15 ± 0.99 | 131.62 ± 14.25 | NA |
| Sharon L. et al. [9] | 1767 (866/901) | 57.20 | 2.76 ± 0.83 | 137.60 ± 18.70 | < 0.01 | 214 (135/79) | 60.10 | 2.71 ± 0.81 | 146.00 ± 20.60 | 0.45 |
| Yong J. et al. [10] | 90 (50/40) | 54.90 | 2.90 ± 0.88 | NA | NA | 90 (46/44) | 54.10 | 2.73 ± 0.82 | NA | 0.18 |
| Su J. et al. [11] | 461 (248/213) | 56.00 | 2.67 ± 0.82 | 134.00 ± 17.00 | 0.10 | 102 (51/51) | 58.40 | 2.60 ± 0.86 | 137.00 ± 19.00 | 0.44 |
| Zhang Y. et al. [12] | 642 (342/300) | 60.03 | 2.92 ± 0.96 | 134.29 ± 19.14 | 0.00 | 417 (247/170) | 61.66 | 2.95 ± 1.15 | 142.50 ± 22.39 | 0.60 |
| Won J. et al. [13] | 2661 (1346/1315) | 59.40 | 2.60 ± 0.09 | 127.00 ± 14.40 | 0.39 | 1338 (593/745) | 62.70 | 2.40 ± 0.90 | 127.50 ± 15.50 | 0.02 |
| Lin X. et al. [53] | 123 (NA) | 52.83 | 3.19 ± 0.94 | 135.52 ± 17.84 | < 0.05 | 77 (NA) | 60.79 | 3.39 ± 1.28 | 143.12 ± 22.72 | > 0.05 |
| Qiao X. et al. [54] | 128 (53/75) | 62.30 | 2.96 ± 0.77 | 133.00 ± 16.00 | 0.03 | 57 (26/31) | 64.50 | 2.98 ± 1.09 | 141.00 ± 13.00 | 0.90 |
| Sadosky A. et al. [34] | 288,328 (134,761/153580) | 61.40 | 2.62 ± 0.85 | NA | NA | 35,050 (17,166/17871) | 64.80 | 2.37 ± 0.84 | NA | 0.00 |
| YM. S. et al. [55] | 785 (403/382) | 54.60 | 2.52 ± 0.81 | 132.00 ± 15.00 | 0.07 | 197 (94/103) | 57.10 | 2.5 ± 0.88 | 135.00 ± 17.00 | 0.76 |
| Khawaja N. et al. [56] | 607 (201/195) | 62.70 | 2.61 ± 0.78 | 142.40 ± 18.10 | <0.01 | 396 (279/328) | 57.80 | 2.64 ± 0.80 | 138.30 ± 17.50 | <0.01 |
| Zhang Q. et al. [57] | 159 (79/80) | 59.75 | 2.68 ± 0.95 | 133.30 ± 18.14 | 0.03 | 95 (48/47) | 64.02 | 2.54 ± 1.16 | 138.85 ± 21.18 | 0.29 |
| Jangh M. et al. [58] | 202 (NA) | 49.40 | 3.39 ± 1.03 | 125.00 ± 21.30 | <0.05 | 608 (NA) | 53.80 | 3.37 ± 0.95 | 129.20 ± 23.40 | 0.90 |
| Kim S. et al. [59] | 761 (360/401) | 62.50 | 2.44 ± 0.84 | 128.00 ± 16.00 | 0.41 | 577 (233/344) | 63.60 | 2.45 ± 0.88 | 127.00 ± 15.00 | 0.98 |
| Bansal D. et al. [14] | 1420 (701/719) | 52.50 | 2.79 ± 1.03 | NA | NA | 586 (288/298) | 57.10 | 2.379 ± 1.20 | NA | <0.01 |
| Buraczy M. et al. [15] | 838 (400/438) | 62.90 | 2.80 ± 1.09 | NA | NA | 406 (194/212) | 63.00 | 2.80 ± 1.05 | NA | 1.00 |
| Luo Y. et al. [16] | 178 (107/71) | 53.00 | 2.70 ± 0.90 | NA | NA | 234 (126/108) | 59.00 | 2.60 ± 0.90 | NA | 0.43 |
| Ren Z. et al. [17] | 385 (191/194) | 66.40 | 2.50 ± 0.80 | 133.00 ± 18.00 | 0.46 | 402 (204/198) | 63.80 | 2.60 ± 0.80 | 132.00 ± 18.00 | 0.15 |
| Andersen S. et al. [44] | 1178 (693/485) | 60.90 | 3.42 ± 0.12 | 148.00 ± 21.00 | <0.05 | 78 (42/36) | 60.60 | 3.10 | 150.50 ± 14.23 | <0.05 |
| Anastasi T. et al. [45] | 274 (143/131) | 63.30 | 3.34 ± 1.40 | 141.20 ± 19.70 | <0.01 | 107 (77/30) | 66.10 | 3.00 ± 1.10 | 150.40 ± 22.90 | 0.02 |
| Xu T. et al. [46] | 397 (111/286) | 62.34 | 3.07 ± 0.90 | 137.14 ± 19.72 | 0.27 | 160 (50/90) | 62.38 | 3.13 ± 1.07 | 135.04 ± 21.36 | 0.50 |
| Zhu T. et al. [52] | 32 (16/16) | 54.38 | 2.64 ± 0.76 | 126.96 ± 11.30 | NA | 32 (15/17) | 56.00 | 2.94 ± 1.23 | 128.97 ± 11.97 | NA |
| Deng W. et al. [51] | 80 (43/37) | 60.68 | 2.71 ± 0.63 | 127.86 ± 16.36 | 0.08 | 122 (72/49) | 60.69 | 2.76 ± 0.70 | 132.64 ± 20.26 | 0.92 |
| Thainá R. et al. [50] | 258 (101/157) | 66.00 | 2.94 ± 1.01 | 142.00 ± 22.00 | 0.07 | 168 (61/107) | 70.00 | 3.04 ± 0.99 | 146.00 ± 23.00 | 0.36 |
| Miric D. et al. [35] | 51 (20/31) | 61.50 | 3.88 ± 1.32 | NA | NA | 29 (13/16) | 62.90 | 4.01 ± 1.45 | NA | NA |
| Hussain G. et al. [42] | 22 (10/12) | 51.90 | 2.29 ± 0.34 | 132.82 ± 10.63 | NA | 64 (28/36) | 54.68 | 2.50 ± 0.59 | 140.00 ± 39.14 | <0.05 |
| Li L. et al. [43] | 2246 (1148/1098) | 57.00 | 3.10 ± 1.19 | 135.70 ± 18.85 | <0.01 | 1113 (459/654) | 62.30 | 3.09 ± 1.12 | 139.27 ± 19.15 | 0.82 |
| Pai Y. et al. [36] | 2223 (1280/943) | 61.90 | 2.64 ± 0.81 | NA | NA | 624 (381/243) | 71.40 | 2.51 ± 0.80 | NA | 0.02 |
| Xu F. et al. [48] | 45 (21/24) | 58.70 | 2.70 ± 0.80 | 139.00 ± 18.00 | 0.19 | 45 (25/20) | 59.80 | 2.30 ± 0.60 | 134.00 ± 18.00 | 0.01 |
| Wang H. et al. [37] | 78 (34/44) | 60.59 | 3.03 ± 0.68 | NA | NA | 129 (54/75) | 61.53 | 2.96 ± 0.88 | NA | NA |
| Wang H. et al. [40] | 150 (73/77) | 60.80 | 3.60 ± 2.20 | 135.00 ± 19.70 | NA | 101 (51/50) | 61.80 | 3.00 ± 1.90 | 127.00 ± 16.50 | NA |
| Pai Y. et al. [39] | 351 (186/165) | 72.50 | 2.54 ± 0.72 | 133.20 ± 15.00 | 0.15 | 275 (147/128) | 73.50 | 2.49 ± 0.73 | 131.25 ± 14.90 | 0.93 |
| Mao F. et al. [22] | 686 (398/288) | 57.73 | NA | 127.81 ± 13.10 | 0 | 264 (157/107) | 63.78 | NA | 131.82 ± 15.33 | NA |
| Hoque S. et al. [33] | 304 (NA) | 49.68 | NA | 127.12 ± 12.62 | 0.20 | 96 (NA) | 51.93 | NA | 129.33 ± 14.66 | NA |
*P-values is calculated LDL mean between the T2DM with and without DPN
**P-values is calculated SBP mean between the T2DM with and without DPN
Abbreviations: N, number; M, male; F, femal; T2DM, type-2 diabetes mellitus; DPN, diabetic peripheral neuropathy; LDL, low-density lipoprotein; SBP, systolic blood pressure; mmol/L, millimole per liter; mmHg, millimeter of Mercury; NA, not avalibale