. Author manuscript; available in PMC: 2019 Nov 26.

Published in final edited form as: Int J Cardiol. 2018 Nov 17;276:212–217. doi: 10.1016/j.ijcard.2018.11.094

Table 1 –

Effect allele frequencies and association of the LPA and 9p21 locus with risk of AVS

		rs10455872 (G)			rs1333049 (C)

Study	Cases/Controls	EAF (Cases/Controls)	OR 95% CI	p-value	EAF (Cases/Controls)	OR 95% CI	p-value
GeneCAST Dundee CAD+	320/1565	0.103/0.079	1.34 (0.97–1.86)	0.076	0.483/0.511	0.89 (0.75.1.06)	0.181
GeneCAST Leicester CAD+	439/993	0.137/0.106	1.33 (1.04–1.70)	0.021	0.489/0.511	0.92 (0.78–1.07)	0.280
GeneCAST Munich CAD+	2054/1340	0.095/0.079	1.23 (1.03–1.46)	0.024	0.507/0.527	0.92 (0.83–1.02)	0.102
Subtotal CAD+	2813/3898		1.27 (1.12–1.45)	2.8×10⁻⁴		0.91 (0.85–0.99)	0.019
GeneCAST Dundee CAD-	340/2056	0.110/0.071	1.62 (1.19–2.22)	0.002	0.468/0.483	0.94 (0.80–1.11)	0.964
GeneCAST Leicester CAD-	520/783	0.102/0.072	1.47 (1.11–1.94)	0.007	0.444/0.472	0.90 (0.77–1.05)	0.470
GeneCAST Munich CAD-	978/1494	0.07/0.047	1.52 (1.20–1.94)	6.5×10⁻⁴	0.472/0.473	1.00 (0.89–1.12)	0.170
Subtotal CAD-	1838/4333		1.53 (1.31–1.79)	1.2×10⁻⁷		0.96 (0.88–1.04)	0.278
Overall	4651/8231		1.37 (1.24–1.52)	6.9×10⁻¹⁰		0.93 (0.88–0.99)	0.014

The effect allele of rs10455872 and rs1333049 is shown in brackets (effect allele). EAF = effect allele frequency. OR 95% CI = Odds ratio 95% confidence interval.