Table 3.
24 genes DE with HFD and their Restoration to Chow Levels with Diet Reversal
| Gene Symbol | HFD v. Chow |
HFD/Chow v. Chow |
HFD/Chow+DHA v. Chow |
HFD/HFD+DHA v. Chow |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Log2 Fold Change |
p-value | Log2 Fold Change |
p-value | Restored to Chow levels |
Log2 Fold Change |
p-value | Restored to Chow levels |
Log2 Fold Change |
p-value | Restored to Chow levels |
|
| Isx | 1.50 | 5.84E-7* | 0.19 | >0.0001 | Yes | 0.055 | >0.0001 | Yes | 0.93 | >0.0001 | Yes |
| Gm42508 | 6.05 | 2.07E-6* | 5.90 | 4.26E-6* | No | 4.42 | 7.0E-4 | No | 6.25 | 1.37E-6* | No |
| Bmper | −0.68 | 6.36E-6* | 0.26 | >0.0001 | Yes | 0.025 | >0.0001 | Yes | −0.29 | >0.0001 | Yes |
| Grid1 | 0.71 | 5.07E-6* | 0.31 | >0.0001 | Yes | 0.37 | >0.0001 | Yes | 0.56 | 6.8E-4 | No |
| Gm13002 | 2.47 | 1.80E-5 | 1.69 | >0.0001 | Yes | 2.58 | 6.30E-6 | No | 2.59 | 1.11E-5 | No |
| 1700024J04Rik | 2.11 | 4.09E-5 | 1.00 | >0.0001 | Yes | 0.84 | >0.0001 | Yes | 2.19 | 3.26E-5 | No |
| Cpn2 | −5.62 | 9.88E-5 | −0.34 | >0.0001 | Yes | −2.91 | >0.0001 | Yes | −0.75 | >0.0001 | Yes |
| Mmrn1 | 0.69 | 2.08E-4 | 0.24 | >0.0001 | Yes | 0.11 | >0.0001 | Yes | 0.78 | 6.28E-5 | No |
| Gm11491 | −1.73 | 5.06E-4 | −1.56 | >0.0001 | Yes | −1.40 | >0.0001 | Yes | −0.47 | >0.0001 | Yes |
| Herc6 | 0.46 | 4.53E-4 | 0.23 | >0.0001 | Yes | 0.093 | >0.0001 | Yes | 0.16 | >0.0001 | Yes |
| Ltbp2 | 0.68 | 5.05E-4 | 0.044 | >0.0001 | Yes | 0.16 | >0.0001 | Yes | 0.77 | 1.7E-4 | No |
| Gm14253 | 1.18 | 4.35E-4 | 0.96 | >0.0001 | Yes | 0.97 | >0.0001 | Yes | 0.84 | >0.0001 | Yes |
| Adra1a | 1.27 | 4.54E-4 | 0.23 | >0.0001 | Yes | 0.19 | >0.0001 | Yes | 1.47 | 1.0E-4 | No |
| Gm45293 | 1.71 | 3.87E-4 | 0.13 | >0.0001 | Yes | 1.13 | >0.0001 | Yes | 1.27 | >0.0001 | Yes |
| 4930519P11Rik | 1.87 | 2.78E-4 | 1.07 | >0.0001 | Yes | 0.42 | >0.0001 | Yes | 1.39 | >0.0001 | Yes |
| Hist1h4m | 2.23 | 3.48E-4 | 3.08 | 4.34E-7* | No | 1.51 | >0.0001 | Yes | 1.88 | >0.0001 | Yes |
| Nat8 | 2.25 | 3.94E-4 | 0.077 | >0.0001 | Yes | 0.25 | >0.0001 | Yes | 0.33 | >0.0001 | Yes |
| Ucma | 1.89 | 5.99E-4 | 1.17 | >0.0001 | Yes | 0.82 | >0.0001 | Yes | 1.24 | >0.0001 | Yes |
| Gm32635 | −1.32 | 9.77E-4 | −0.11 | >0.0001 | Yes | −0.35 | >0.0001 | Yes | −0.50 | >0.0001 | Yes |
| Flt4 | 0.37 | 9.85E-4 | 0.22 | >0.0001 | Yes | 0.079 | >0.0001 | Yes | 0.45 | 1.9E-4 | No |
| Klhl34 | 1.02 | 9.56E-4 | 0.42 | >0.0001 | Yes | 0.49 | >0.0001 | Yes | 0.70 | >0.0001 | Yes |
| Gm44974 | 1.62 | 8.42E-4 | 0.89 | >0.0001 | Yes | 1.02 | >0.0001 | Yes | 1.15 | >0.0001 | Yes |
| 9330188P03Rik | 1.74 | 9.20E-4 | 2.38 | 4.54E-6* | No | 1.18 | >0.0001 | Yes | 1.58 | >0.0001 | Yes |
| Gm34885 | 1.95 | 7.69E-4 | 1.95 | 8.0E-4 | No | 1.64 | >0.0001 | Yes | 1.78 | >0.0001 | Yes |
Log2 Fold Change values and p-values for the 24 DE genes in HFD mice compared to chow controls are listed. The log2 Fold Change compared to chow controls for each of the three dietary interventions and the corresponding p-value for each of HFD-induced-DE genes are provided to show which were restored to chow levels in each dietary intervention.
*
Corresponding FDR adjusted p-value <0.05.